The product can tolerate some mild temperature excursions (held above the recommended storage temperature) with no or only limited loss of probiotic viability. When left uncovered for long periods of time the product might become contaminated from the environment and also would have increased oxidation of the suspending corn oil. These would potentially shorten the product shelf life after opening (we suggest discarding 6 weeks after opening). Excessive heat would reduce the number of beneficial bacteria present. So while the product would be less efficacious it would not be harmful if used.